AIDS may be one of the most undesirable diseases in the world. Luckily, there is now hope for AIDS patients. According to a recent paper published in the New England Journal of Medicine, Chinese scientists have successfully used CRISPR technology-a method of gene editing-to treat a patient with HIV. While it may not have cured the patient fully, it still represents a huge step forward in fighting the disease.
The patient was a 27-year-old Chinese man who was diagnosed with both AIDS and acute lymphoblastic leukemia, a type of blood cancer. Despite his bleak situation, doctors offered him a glimmer of hope: a bone marrow (骨髓) transplant to treat his cancer and an experimental treatment for his HIV.
They edited the DNA in bone marrow stem cells from a donor before transplanting the cells into the patient. Specifically, the treatment involved using the gene-editing tool CRISPR-Cas9 to delete a gene known as CCRS, which encodes a protein that HIV uses to get inside human cells. Without the gene, HIV is unable to enter cells. Talking about the gene, lead scientist Deng Hongkui told CNN, “After being edited, the cells-and the blood cells they produce-have the ability to resist HIV infection.” Nineteen months after the treatment, the patient’s leukemia was in complete relief and donor cells without CCR5 remained, according to the research paper.
Though the transplant did not cure the man’s HIV, it still showed the effectiveness of gene-editing technology, as there was no indication of any unintended genetic alterations (改变) -a major concern with past gene therapy experiments.
Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security in the United States, who was not involved in the study, praised the treatment. “They did a very innovative experiment, it was safe,” he told Live Science. “It should be viewed as a success.”
Deng believes gene-editing technology could “bring a new dawn” to blood-related diseases such as AIDS and sickle cell anemia. Thanks to this new technology, “the goal of a functional cure for AIDS is getting closer and closer,” he said.
1.How did the new treatment fight against HIV?
A.By preventing HIV from entering cells. B.By changing the structure of HIV.
C.By removing a protein that HIV feeds on. D.By identifying and killing HIV.
2.What was the result of the treatment?
A.CCR5 and other genes in the patient’s cells were changed.
B.Some of the patient’s blood cells could resist HIV infection.
C.HIV could no longer get into the patient’s cells.
D.The donor cells without CCR5 disappeared finally.
3.What do we know about the experiment?
A.It has provided an innovative way to cure AIDS patients.
B.It pointed out the problems of gene therapy for AIDS.
C.It’s the first experiment to use gene-editing technology to treat AIDS.
D.It could offer a safe treatment for blood-related diseases.
高三英语阅读理解中等难度题
AIDS may be one of the most undesirable diseases in the world. Luckily, there is now hope for AIDS patients.
According to a recent paper published in the New England Journal of Medicine，Chinese scientists have successfully used CRISPR technology -a method of gene editing-to treat a patient with HIV. While it may not have cured the patient fully, it still represents a huge step forward in fighting the disease.
The patient was a 27-year-old Chinese man who was diagnosed with both AIDS and acute lymphoblastic leukemia (淋巴母细胞白血病), a type of blood cancer. Despite his bleak situation, doctors offered him a little hope: a bone marrow (骨髓) transplant to treat his cancer and an experimental treatment for his HIV. They used this chance to edit the DNA in bone marrow stem cells (干细胞) from a donor before transplanting the cells into the patient.
Specifically, the treatment involved using the gene-editing tool CRISPR-Cas9 to delete a gene known as CCR5, which encodes (给…编码) a protein that HIV uses to get inside human cells. Without the gene, HIV is unable to enter cells. Talking about the gene, lead scientist Deng Hongkui told CNN, “After being edited, the cells and the blood cells they produce have the ability to resist HIV infection.” Nineteen months after the treatment, the patients leukemia was in complete remission( 缓 解 ) and donor cells without CCR5 remained, according to the research paper.
Though the transplant didn't cure the man’s HIV, it still showed the effectiveness of gene-editing technology, as there was no indication of any unintended genetic changes-a major concern with past gene-editing treatment experiments. Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security in the United States, who was not involved in the study, praised the treatment. “They did a very creative experiment, and it was safe,” he told Live Science. “It should be viewed as a success.”
Deng believes gene-editing technology could “bring a new dawn” to blood related diseases such as AIDS and sickle-cell anaemia ( 镰 状 细 胞 贫 血 ). “Thanks to this new technology, the goal of a functional cure for AIDS is getting closer and closer,” he said.
1.The underlined word “bleak” in Paragraph3 probably means “______”.
A.hopeless
B.unstable
C.embarrassing
D.unique
2.How did the treatment fight against HIV?
A.By identifying and killing HIV.
B.By changing the structure of HIV.
C.By preventing HIV entering cells.
D.By removing a protein HIV feeds on.
3.What is the result of the treatment?
A.Gene-edited cells are able to resist HIV infection.
B.The number of cells infected by HIV has decreased.
C.CCR5 and other genes in the patient's cells are changed.
D.Unintended genetic changes have taken place in the patient's cells.
4.What can we know about the experiment?
A.It pointed out the problems of gene treatment.
B.It provided a new way to cure AIDS patients fully.
C.It could offer a safe treatment for blood-related diseases.
D.It was the first example to use gene-editing tool to treat AIDS.
高三英语阅读理解困难题查看答案及解析
AIDS may be one of the most undesirable diseases in the world. Luckily, there is now hope for AIDS patients. According to a recent paper published in the New England Journal of Medicine, Chinese scientists have successfully used CRISPR technology-a method of gene editing-to treat a patient with HIV. While it may not have cured the patient fully, it still represents a huge step forward in fighting the disease.
The patient was a 27-year-old Chinese man who was diagnosed with both AIDS and acute lymphoblastic leukemia, a type of blood cancer. Despite his bleak situation, doctors offered him a glimmer of hope: a bone marrow (骨髓) transplant to treat his cancer and an experimental treatment for his HIV.
They edited the DNA in bone marrow stem cells from a donor before transplanting the cells into the patient. Specifically, the treatment involved using the gene-editing tool CRISPR-Cas9 to delete a gene known as CCRS, which encodes a protein that HIV uses to get inside human cells. Without the gene, HIV is unable to enter cells. Talking about the gene, lead scientist Deng Hongkui told CNN, “After being edited, the cells-and the blood cells they produce-have the ability to resist HIV infection.” Nineteen months after the treatment, the patient’s leukemia was in complete relief and donor cells without CCR5 remained, according to the research paper.
Though the transplant did not cure the man’s HIV, it still showed the effectiveness of gene-editing technology, as there was no indication of any unintended genetic alterations (改变) -a major concern with past gene therapy experiments.
Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security in the United States, who was not involved in the study, praised the treatment. “They did a very innovative experiment, it was safe,” he told Live Science. “It should be viewed as a success.”
Deng believes gene-editing technology could “bring a new dawn” to blood-related diseases such as AIDS and sickle cell anemia. Thanks to this new technology, “the goal of a functional cure for AIDS is getting closer and closer,” he said.
1.How did the new treatment fight against HIV?
A.By preventing HIV from entering cells. B.By changing the structure of HIV.
C.By removing a protein that HIV feeds on. D.By identifying and killing HIV.
2.What was the result of the treatment?
A.CCR5 and other genes in the patient’s cells were changed.
B.Some of the patient’s blood cells could resist HIV infection.
C.HIV could no longer get into the patient’s cells.
D.The donor cells without CCR5 disappeared finally.
3.What do we know about the experiment?
A.It has provided an innovative way to cure AIDS patients.
B.It pointed out the problems of gene therapy for AIDS.
C.It’s the first experiment to use gene-editing technology to treat AIDS.
D.It could offer a safe treatment for blood-related diseases.
高三英语阅读理解中等难度题查看答案及解析
Stephen Hawking is one of the most famous scientists in this century. He was born in 1942. He’s world well-known on space and time. Stephen was searching some very big questions, such as How did the universe begin? How will it end?
Stephen was a student at Oxford University. He studied math and science. Then, at the age of twenty, he became sick. He was so young, but the doctors said to his family, “He has only two more years to live.” As a matter of fact, the doctors were wrong – he didn’t die. He can’t walk but he uses a wheelchair. He can’t feed himself and get in or out of bed himself. But he refused to give in to the condition. He talks with the help of a computer. After Oxford, Stephen went to Cambridge University. Three years later, in 1965, he became a doctor of philosophy(哲学).
Because of his serious health problems, it was difficult for him to draw diagrams(图表) or to write. So he started to think in pictures. With this new way of thinking, he became one of the most famous scientists in the world. In 1981, he met the Pope(教皇) in Rome. They talked about his ideas. Then in 1988, he wrote his first important book, A Brief History of Time. It sold more than 5.5 million copies in 33 different languages. He was once invited to China, he impressed us with his self-confidence, humorous and witty conversation.
1.A Brief History of Time is ________.
A. a book which is well-known all over the word
B. a book about Rome’s history
C. Stephen’s talk collection with the Pope in Rome
D. Stephen’s talk collection with me in China
2.Stephen’s studies DO NOT relate to ________ according to the passage.
A. science B. math
C. philosophy D. art
3.The right order of Stephen’s main experiences in ________.
a. He went to Cambridge University.
b. He became very ill.
c. He wrote his first important book.
d. He met the Pope in Rome.
A. c-a-b-d B. a-b-c-d
C. b-a-d-c D. a-c-b-d
4.What does the underlined word “witty” mean?
A. Inspiring. B. Confident.
C. Intelligent. D. Funny.
高三英语阅读理解中等难度题查看答案及解析
Watching wooden dolls come to life may not be one of the most popular forms of entertainment today, but with over twenty years’ experience, talented puppeteer (木偶表演者) Peter Roberts has earned himself the title “master puppeteer” because of his great ability to turn puppets into believable, almost living characters. “People are quite often surprised to hear what I do for living and have little appreciation of puppy as a form of entertainment. But while the exact origins of puppet theatre are unknown, it has been popular in many cultures and may have been the very first kind of theatre,” he explains.
Roberts’ shows are highly original. “A puppet show can involve anything from clowning(傻逗) to storytelling,” he says, Equally diverse are the audiences he performs for. “Some are attracted by the puppets themselves, while others enjoy the dialogue.” Roberts believes that this form of entertainment can be appreciated by people of all ages and cultures.
Roberts’ interest in puppets started when he received some beautiful glove puppets one Christmas. He started putting on shows with these for family and friends and then moved on to handmade Chinese string puppets. Learning mostly from books and personal experience, he explains, “I was already spending most of my free time carving puppets and putting on shows, so I hardly noticed the change from students to full-time professional puppeteer.”
The puppets are designed specifically for each show, which is extremely time consuming. According to Roberts, “Sometimes what you expect and what you actually create in the end are two very different things. I’ve made some of my best puppets ‘accidentally’.”
When most people hear the word “puppetry”, they more than likely think of a way of keeping children entertained at birthday parties. Certainly the subject matter will be expected to be light-hearted rather than serious. However, Roberts wants to point out that puppets come serious messages sometimes.” he says.
1.What do we know about puppetry in the first paragraph?
A. It is a most popular form of entertainment.
B. It cannot give people pleasure any more.
C. It was first brought to life by Peter Roberts.
D. Its value as an art form is not fully recognized.
2.In Roberts’ eyes, his puppet shows .
A. usually attract people full of humor
B. are most something for old aged audience
C. display something meaningful for different people
D. involve hard work and great intelligence
3.Roberts developed an interest in puppets because of .
A. the puppet show books
B. his university major
C. a Christmas gift
D. some Chinese string puppets
4.What does Roberts want people to think of puppet theatre?
A. It is just a kind of entertainment for kids.
B. It can be educational as well as entertaining.
C. It is only a kind of serious art form.
D. It should be kept light-hearted.
高三英语阅读理解中等难度题查看答案及解析
Watching wooden dolls come to life may not be one of the most popular forms of entertainment today, but with over twenty years’ experience, talented puppeteer (木偶表演者) Peter Roberts has earned himself the title “master puppeteer” because of his great ability to turn puppets into believable, almost living characters. “People are quite often surprised to hear what I do for a living and have little appreciation of puppy as a form of entertainment. But while the exact origins of puppet theatre are unknown, it has been popular in many cultures and may have been the very first kind of theatre,” he explains.
Roberts’ shows are highly original. “A puppet show can involve anything from clowning(傻逗) to storytelling,” he says. Equally diverse are the audiences he performs for. “Some are attracted by the puppets themselves, while others enjoy the dialogue.” Roberts believes that this form of entertainment can be appreciated by people of all ages and cultures.
Roberts’ interest in puppets started when he received some beautiful glove puppets one Christmas. He started putting on shows with these for family and friends and then moved on to handmade Chinese string puppets. Learning mostly from books and personal experience, he explains, “I was already spending most of my free time carving puppets and putting on shows, so I hardly noticed the change from students to full-time professional puppeteer.”
The puppets are designed specifically for each show, which is extremely time consuming. According to Roberts, “Sometimes what you expect and what you actually create in the end are two very different things. I’ve made some of my best puppets ‘accidentally’.”
When most people hear the word “puppetry”, they more than likely think of a way of keeping children entertained at birthday parties. Certainly the subject matter will be expected to be light-hearted rather than serious. However, Roberts wants to point out that puppets convey serious messages sometimes.” he says.
1.What do we know about puppetry in the first paragraph?
A. It is a most popular form of entertainment.
B. It cannot give people pleasure any more.
C. It was first brought to life by Peter Roberts.
D. Its value as an art form is not fully recognized.
2.In Roberts’ eyes, his puppet shows .
A. usually attract people full of humor
B. are most something for old aged audience
C. display something meaningful for different people
D. involve hard work and great intelligence
3.Roberts developed an interest in puppets because of .
A. the puppet show books B. his university major
C. a Christmas gift D. some Chinese string puppets
4.What does Roberts want people to think of puppet theatre?
A. It is just a kind of entertainment for kids.
B. It can be educational as well as entertaining.
C. It is only a kind of serious art form.
D. It should be kept light-hearted.
高三英语阅读理解中等难度题查看答案及解析
To send and to read email has quickly become one of the most common daily activities around the world, either for business or pleasure. ________1.________
Several reasons why email has become a great tool is that it is fast, convenient, and affordable.________2.________In the past, teachers often organized pen friends project where their students would exchange letters with another group of students in another country ________3.________And by that time, students might lose interest in the project or the class might and before a serious of meaningful exchanges can take place. ________4.________With email, however, messages can be sent at a click of a button at school, home, or an Internet café, and if you are using a free email account, the cost is free(not taking into account any Internet Service Provider fees that you have to pay).
________5.________Email has a lot to offer, for language learners and teachers in the classroom.
A．In addition, students have to pay imitational postage to send the letters.
B．However, the turn-arcund time for sending and receiving traditional letters can take up months.
C．Now, more students are using this form of communication to improve their language skills.
D．Students can develop friendships with people from around the globe.
E．While chatting online, never give out personal information including your age.
F．One particular activity that takes advantage of these points is a key pal exchange.
G．Instead of waiting days or weeks for a response, students can receive a reply quickly.
高三英语其他题中等难度题查看答案及解析
How to revise for a test
Studying for tests may be one of the most difficult parts of school. 1. If you feel discouraged about an approaching test and need some directions for preparing yourself, consider using the following suggestions to help you out.
Aim foremost to understand the concepts.
Keep the important points in mind, and ignore unnecessary information. 2.
Ask for help.
When the need arises, it is best to receive help from the others. 3. You could also ask him/ her for a set of questions and answers that could help you memorize the information. You could also ask a family member or a friend for help.
Practice in everyday life.
Fit reviewing into everyday life by sticking up notes with sentences you need to remember for the test written upon them. 4. You could possibly put one on the bathroom mirror, one at the table and another by the TV. This is optional but highly recommended.
5.
Find out how much you remember certain things and what’s missing. Decide what you did well in and what you did not so well in. This may boost your chances of getting more marks in the assessment and may also help you remember for next time. For instance, if you are struggling on maths problems based on geometry, then put this down as something that you need to review more than the subjects you are good at.
Review often but little.
Do not push yourself and try reviewing everything in one day. Practice takes time and if you rush, you won’t remember anything.
A. Go through what you have been learning.
B. Mark your practice tests.
C. As long as you remain focused on the main topics, you will be able to do well on the test.
D. However, even the worst test performance could be turned around into a successful attempt.
E. It can be difficult to remember the material and understand which points to study.
F. You will notice them every day and reviewing won’t seem to be boring or dull.
G. Ask your teacher to summarize the topic with all the important points.
高三英语七选五中等难度题查看答案及解析
Although cats may be one of the most popular pets today, little is known about how and when humans and cats set up their close relationship.
The earliest evidence for human–cat interaction dates back to prehistoric Cyprus（史前塞浦路斯）, where the remains of a wild cat and a human — dated 9,500 years old — were found buried together.
A new study in the Proceedings of the National Academy of Sciences has confirmed the first direct evidence of a human–domestic cat relationship among Chinese farmers 5,300 years ago. Researchers studied the bones of cats, dogs, deer and other animals unearthed in an excavation (挖掘) near a village in Central China. By using some ways, scientists showed that the cats were living on a mostly millet(黍)–based diet, just like the domesticated dogs and pigs from the site.
"The most reasonable explanation for a high consumption of millet–based food is that the cats had formed a stable and mutual relationship with humans and could easily feed on rodents (啮齿动物) around human villages, find leftover food or even have been fed by people intentionally," said Hu Yaowu from the Chinese Academy of Sciences in Beijing, whose research focuses on the relationship between humans and domesticated animals.
"It is very interesting for us to find the consumption of millet-based foods by the cats, since this kind of evidence had long been missing.” Hu explains. Since cats usually eat meat, such a diet would be unexpected, unless the cats were being fed by people, the study argues. The researchers also found that one of the cats survived to reach old age, implying that it had a safe place to live and enough to eat.
Why the farmers wanted to keep cats nearby or make them "pets" could be answered by other evidence. Chinese archaeologists found some storage containers were specifically designed to keep out rodents — a vermin (害兽) that cats could certainly have helped with.
The simplified theory is that rats were attracted to the food of farmers, and so were harmful to farmers. Cats were attracted to the rats, and so farmers formed a mutually beneficial relationship with cats, taking care of them in return for pest control.
1.The evidence found in the remains dating back to prehistoric Cyprus means .
A. human made cats pets as early as 9,500 years ago
B. human interacted with cats very early
C. cats didn’t appear until prehistoric Cyprus
D. when cats became domesticated
2.Apart from cats, Hu Yaowu and his teams may also study .
A. the preventions of pests from grains
B. the history of Chinese farming
C. the dogs and pigs
D. the ways to keep pets
3.Which of the following is NOT the evidence of Chinese farms’ keeping cats?
A. Cats didn’t feed on meat.
B. The cats consumed large amounts of millet–based foods.
C. One of the cats survived to reach old age.
D. Some storage containers were specifically designed to keep out rodents.
4.What are the reasons for farmers to keep cats?
A. Helping keep other domesticated animals.
B. Not letting cats eat food.
C. Supplying meat for human.
D. Helping reduce the amount of pests.
5.In which part of a newspaper would be the passage most probably appear .
A. Entertainment B. Environment
C. Human and Science D. Life and fashion
高三英语阅读理解中等难度题查看答案及解析
Doctors Say Most Heart Disease Preventable
Heart disease is the number one killer, worldwide, of men and women over the age of 60. But people of all ages die of heart attacks each year. And while death rates have declined in the U.S. and many western European countries, they are on the rise in the developing world. 1.________.
No one would have guessed that Barbara Teng would have a heart attack. She was not overweight. She did not smoke or exercise.“In 2004, the week after I turned 49, when I was on a business trip in Chicago, I had a major heart attack," she said. 2.________. She now exercises daily, and monitors her heart health.
Dr. Patrice Nickens, who is with the National Heart, Lung and Blood Institute, thinks that heart disease is 82 percent preventable. “3.________,” she said, “Men are also facing the same problem, and the key to staying healthy is knowing your numbers”.
“Your weight, your blood cholesterol, blood sugar and your blood pressure are important numbers that can help you take action and reduce your risk,” she said.
4.________.
“And the steps to take are simple: don’t smoke, maintain a healthy weight, exercise, know your numbers and talk to your physician and control these risks,” she said.
African-Americans are at higher-than-average risk for heart disease and stroke; people don't even know they have it, which increases the risk. Medstar Washington Hospital Center is trying to reach this population. 5.________. For example, helping the people monitor their blood pressure. If people realize they are at risk for heart disease, they'll make lifestyle changes: lose weight, exercise, eat the right foods and keep in touch with a doctor
A. A healthy lifestyle can prevent heart disease
B. So we must cure heart disease
C. It is the leading cause of death for women
D. With the right training, they can play an important role in community health
E. And that changed her life
F. Lack of exercise causes heart attacks
G. Yet most heart disease is preventable.
高三英语信息匹配中等难度题查看答案及解析
England continues to be one of the most popular tourist destinations in the world. London in particular is one of the most visited cities and draws people in with its appeal, history, and pubs. England’s smaller cities, like Bath and Oxford, are equally as attractive with a lot of culture and fewer crowds. Liverpool, birthplace of The Beatles, has a rich musical history. The countryside has wonderful natural beauty. Here are some tips on traveling in England.
Free museums—Public museums offer free admission in every city throughout England and the UK. It’s a great way to learn about the country’s most influential artists and history, and spend a rainy day without paying a cent.
Book early—Book all transportation well in advance, even if you don’t plan to use it. Fares can be around ￡2 with a little planning. The Megabus not only runs buses but also provides trains throughout England and is the best choice for cheap travel throughout the country.
Pub food—Eating in England can be quite expensive, but for good cheap and filling meals, visit the local pubs, where you can get a good meal for less than ￡10. Besides, the pubs are a great way to meet people!
Get a Taste of UK card—The Taste of the UK card offers up to 50% off at selected restaurants. You don’t need to be an English to get the card, and you needn’t pay the first month’s membership fee, which is perfect for most travelers.
Take a free walking tour—Many major cities in England offer free walking tours. They usually last a few hours and are a great way to see the city.
1.Compared with London, Oxford is .
A. more appealing B. less crowded
C. larger in size D. richer in history
2.Why is eating in local pubs suggested?
A. The price of food is low there.
B. The chance of meeting stars is high there.
C. The service is excellent there.
D. The dining atmosphere is perfect there.
3.What can be known from the text?
A. All museums in the UK are free of charge.
B. The best way to travel around England is by bus.
C. Free walking tours are available in only some cities in England.
D. Holders of the Taste of UK card can enjoy discounts at all restaurants.
高三英语阅读理解中等难度题查看答案及解析