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“ New and improved. ” These words are put in so many marketing campaigns that we tend to accept them as linked. But many new drugs aren't an improvement over the best existing drug for a given condition, and the fast drug-approval processes in recent years have added to the uncertainty about their advantages.
A recent report in the British Medical Journal, "New Drugs: Where Did We Go Wrong and What Can We Do Better?, analysed the issue, The authors looked at 216 drugs approved between 2011 and 2017 ； 152 were newly developed, and 64 were existing medicine approved for new uses. Only 25% offered a major advantage over the established treatment, and fully 58% had no confirmed added benefit to reduce symptoms or improve health-related quality of life.
"This doesn’t mean there's no added benefit," lead author Wieseler said. “It just means we have no positive proof. Either we have no studies or have studies not good enough. ” Wieseler and her co-authors work for a German institute which evaluates new treatments and advises on whether the country's health care system should pay a premium ( 占)for them. Such organizations , known as health technology assessment ( HTA) agencies, work a little differently in the US, says Sean Tunis，a researcher in Baltimore: “ If payers think a new drug isn't better than an existing drug，these agencies will require .that hospitals try the cheaper drug first. ”
Germany's HTA demands trials to prove that a new treatment beats the existing standard. This isn't always practical For one thing, such studies can be expensive and time-consuming, with no guarantee of success. Secondly, it can discourage companies from attempting to develop new alternatives. This is already happening. Drug developers are increasingly focused on areas where there are no good treatments to compete with, such as rare diseases.
This lack of meaningful data to guide patients is a major point of Wieseler's paper- With accelerated approval, there are more products approved, with a greater amount of uncertainty about risks and benefits. But there are other solutions besides drug trials. One idea is to require postmarket studies to track the effectiveness of newly approved drugs—a step too often neglected.
1.What message does the recent report convey?
A.Many new drugs have no improved advantages.
B.The approval processes for new drugs are too fast.
C.Improved drugs have advantages over old ones.
D.Before 2017 no improvement was made to drugs.
2.What will US HTA agencies do when no advantage is found in new drugs?
A.Remove government premium on them.
B.Get hospitals to use the cheaper drugs.
C.Arrange financial support for the patients.
D.Put new drugs on further trials and studies.
3.What's the disadvantage of Germany's HTA trial demands?
A.Making drug companies think of illegal ways to cut cost.
B.Pushing companies to try alternatives for existing drugs.
C.Getting patients to depend on the government for support.
D.Holding companies back from improving existing drugs.
4.What is the best title for the text?
A.The Advantage of Existing Drugs
B.Misunderstanding of New and Old Drugs
C.A Dilemma with New Drug Alternatives
D.Peopled Preference for New or Old Drugs
高三英语阅读理解中等难度题查看答案及解析
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＂New and improved."These words are put in so many marketing campaigns that we tend to accept them as linked.But many new drugs aren't an improvement over the best existing drug for a given condition,and the fast drug-approval processes in recent years have added to the uncertainty about their advantages.
A recent report in the British Medical Journal,"New Drugs;Where Did We Go Wrong and What We Do Better?" analyzed the issue,The authors looked at 216 drugs approved between 2011 and 2017; 152 were newly developed,and 64 were existing medicine approved for new uses. Only 25% offered a major advantage over the established treatment,and fully 58% had no confirmed added benefit to reduce symptoms or improve health-related quality of life.
＂This doesn't mean there's no added benefit,"lead author Wieseler said."It just means we have no positive proof Either we have no studies or have studies not good enough.”Wieseler and her co-authors work for a German agency which evaluates new treatments and advises on whether the country's health care system should pay a premium(补贴）for them.If payers think a new drug isn't better than an existing drug,these agencies will require that hospitals try the cheaper drug first.
Germany's HTA demands trials to prove that a new treatment beats the existing standard. This isn't always practical. For one thing, such studies can be expensive and time-consuming,with no guarantee of success.Secondly,it can discourage companies from attempting to develop new alternatives.This is already happening.Drug developers are increasingly focused on areas where there are no good treatments to compete with,such as rare diseases.
This lack of meaningful data to guide patients is a major point of Wieseler's paper.With accelerated approval,there are more products approved,with a greater amount of uncertainty about risks and benefits. But there are other solutions besides drug trials.One idea is to require postmarket studies to track the effectiveness of newly approved drugs-a step too often neglected.
1.What message does the recent report convey?
A.Improved drugs have advantages over old ones.
B.The approval processes for new drugs are too fast.
C.Many new drugs have no improved advantages.
D.Almost half the drugs approved target the special cases.
2.What's the disadvantage of Germany's HTA trial demands?
A.Making drug companies think of illegal ways to cut cost.
B.Holding companies back from improving existing drugs.
C.Getting patients to depend on the government for support.
D.Pushing companies to try alternatives for existing drugs.
3.What is the best title for the text?
A.The Advantage of Existing Drugs B.The Great Potential of New Drugs
C.People's Preference for New or Old Drugs D.A Dilemma with New Drug Alternatives
高三英语阅读理解中等难度题查看答案及解析
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“New and improved. “These words are put in so many marketing campaigns that we tend to accept them as linked. But many new drugs aren’t an improvement over the best existing drug for a given condition, and the fast drug-approval processes in recent years have added to the uncertainty about their advantages.
A recent report in the British Medical Journal, “New Drugs: Where Did We Go Wrong and What Can We Do Better? “Analyzed the issue. The authors looked at 216 drugs approved between 2011 and 2017:152 were newly developed, and 64 were existing medicine approved for new uses. Only 25%offered a major advantage over the established treatment, and fully 58%had no confirmed added benefit to reduce symptoms or improve health-related quality of life.
“This doesn’t mean there’s no added benefit, “lead author Wissler said. “It just means we have no positive proof. Either we have no studies or have studies not good enough. “Wissler and her co-authors work for a German institute which evaluates new treatments and advises on whether the country’s health care system should pay a premium(补贴)for them. Such organizations, known as health technology assessment(HTA)agencies, work a little differently in the US, says Sean Tunisia researcher in Baltimore: “If payers think a new drug isn’t better than an existing drug, these agencies will require that hospitals try the cheaper drug first.”
Germanys HTA demands trials to prove that a new treatment beats the existing standard. This isn’t always practical. For one thing, such studies can be expensive and time-consuming, with no guarantee of success. Secondly, it can discourage companies from attempting to develop new alternatives. This is already happening. Drug developers are increasingly focused on areas where there are no good treatments to compete with, such as rare diseases.
This lack of meaningful data to guide patients is a major point of Wissler’s paper. With accelerated approval, there are more products approved, with a greater amount of uncertainty about risks and benefits. But there are other solutions besides drug trials. One idea is to require postmarked studies to track the effectiveness of newly approved drugs—a step too often neglected.
1.What message does the recent report convey?
A.Improved drugs have advantages over old ones.
B.Many new drugs have no improved advantages.
C.Before 2017 no improvement was made to drugs.
D.The approval processes for new drugs are too fast.
2.What will US HTA agencies do when no advantage is found in new drugs?
A.Get hospitals to use the cheaper drugs.
B.Remove government premium on them.
C.Arrange financial support for the patients.
D.Put new drugs on further trials and studies.
3.What’s the disadvantage of Germany’s HTA trial demands?
A.Getting patients to depend on the government for support.
B.Making drug companies think of illegal ways to cut cost.
C.Holding companies back from improving existing drugs.
D.Pushing companies to try alternatives for existing drugs.
4.What is the best title for the text?
A.The Advantage of Existing Drugs
B.A Dilemma with New Drug Alternatives
C.Misunderstanding of New and Old Drugs
D.People’s Preference for New or Old Drug
高三英语阅读理解困难题查看答案及解析
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There are the two simple words, “if” and “what”. These two words can be used in many sentences and questions by themselves, but if you put them together, it forms a serious question, “What if…?”
This question will bring you back to a certain time in your life when you made a choice. You may not be happy with that choice today and often think about why you did it, but you made the decision because it was the best choice at that specific moment in your life. Now, years later, you start to think about that specific choice you made. You mentally struggle with yourself and consider if you could choose again, what would you do? Would it be totally different?
I truly believe if you want something very much, you can do it and achieve it , because “Where there is a will, there is a way.” You can correct the mistakes of your decisions for the past, go out and find happiness in the right decisions for your future. It is never too late to do anything in life.
【写作内容】
1. 以约30个词概括上文的主要内容。
2. 以约120个词就“人生努力永不晚”谈一谈你的看法，内容包括：
(1) 你对人生努力的理解；
(2) 举一个“大器晚成”的例子；
(3) 你对实例的评价或看法。
【写作要求】
1. 作文中可以使用实例来支持你的论点，也可以参照阅读材料的内容论述，但不得直接引用原文中的句子；
2. 作文中不能出现真实姓名和学校名称。
【评分标准】
概括准确，语言规范，内容合适，篇章连贯。
________________________________________________________
________________________________________________________
________________________________________________________
高三英语书面表达中等难度题查看答案及解析
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There are the two simple words, “if” and “what”. These two words can be used in many sentences and questions by themselves, but if you put them together, it forms a serious question, “What if…?”
This question will bring you back to a certain time in your life when you made a choice. You may not be happy with that choice today and often think about why you did it, but you made the decision because it was the best choice at that specific moment in your life. Now, years later, you start to think about that specific choice you made. You mentally struggle with yourself and consider if you could choose again, what would you do? Would it be totally different?
I truly believe if you want something very much, you can do it and achieve it , because “Where there is a will, there is a way.” You can correct the mistakes of your decisions for the past, go out and find happiness in the right decisions for your future. It is never too late to do anything in life.
【写作内容】
1. 以约30个词概括上文的主要内容。
2. 以约120个词就“人生努力永不晚”谈一谈你的看法，内容包括：
(1) 你对人生努力的理解；
(2) 举一个“大器晚成”的例子；
(3) 你对实例的评价或看法。
【写作要求】
1. 作文中可以使用实例来支持你的论点，也可以参照阅读材料的内容论述，但不得直接引用原文中的句子；
2. 作文中不能出现真实姓名和学校名称。
【评分标准】
概括准确
，语言规范，内容合适，篇章连贯。高三英语书面表达中等难度题查看答案及解析
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Just as the stock market rises and falls in response to what people are willing to put their money behind, we have inside ourselves an inner economy that rises and falls in response to our beliefs about what is possible. Sometimes the degree to which we are willing to our belief systems determines the success of our inner economy. For example, imagine that your family of origin had a belief that musical talent was not something they . As a member of that group, you would likely that same belief about yourself. As a result, even if you had a great desire to create music, you might be to really get behind yourself. Because you might fear that your would not pay off. Even if you had the courage to follow your passion, your inner belief that you are not born would probably stop your trying. And that would be a major to invest your energy in your dream.
On the other hand, belief isn’t anything . If you found a way to that negative belief, a great flood of energy would pour forth, greatly increasing the possibility of your success. How much energy we are willing to invest in the various ideas and dreams is like the money people are, or are not, willing to invest in the various products available for trade on the stock market. And in both cases, plays a key role in determining how willing we are to get behind something. One way to open up the possibility for greater success in our inner economies is to understand that belief is not the reliable we sometimes think. There are other more reliable things of success that we can put our in, such as passion, feeling, and sense. Some of the most successful investors in the stock market are the ones that go against the grain, trusting their sense over the opinion held by ordinary people about what will work.
In the same way, we can learn to trust our heart’s desires and our sense to guide us,
any beliefs that stand in the way of our ability to fully invest in ourselves. As we take out energy from limiting ideas about what is possible, we the resources that have the power to make our inner economy prosper.
1.A. simplify B. challenge C. eliminate D. maintain
2.A. possessed B. trusted C. objected D. missed
3.A. reject B. preserve C. deny D. share
4.A. willing B. sorry C. reluctant D. ready
5.A. success B. knowledge C. profession D. investment
6.A. devoted B. talented C. concerned D. interested
7.A. obstacle B. excuse C. chance D. principle
8.A. important B. fixed C. changeable D. stimulating
9.A. enhance B. reserve C. release D. follow
10.A. energy B. hobby C. expense D. belief
11.A. guide B. ability C. goal D. policy
12.A. aim B. faith C. task D. dream
13.A. unacceptable B. strange C. unbelievable D. common
14.A. questioning B. understanding C. interpreting D. believing
15.A. stick to B. lead to C. free up D. leave out
高三英语完形填空中等难度题查看答案及解析
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In an age dominated （控制的） by new media and the Internet, there are so many alternative ways of learning．Gone are the days when, if we couldn't make it into a classroom, the only real option was to pick up a book, or when audio materials consisted of bad quality cassettes or sporadic（时有时无的） radio and TV programmes．With the appearance of broadband access to the web, we have a whole new learning domain （统领） at our fingertips．Sophisticated learning materials in the form of text or high-quality audio are now available at the touch of a button, and tests and assignments can be submitted （进行） and marked online．Questions and learning, studying away from the classroom has never seemed easier．Yet many teachers would argue that face-to-face contact between teachers and students is an essential part of the language learning experience．Enter the concept of blended （融合的） learning, an approach to education which seeks to combine the best of new technology and actual human contact．
Advocates of blended learning argue that an approach to study which combines the benefits of new technology with the best aspects of face-to-face （often abbreviated to F2F） teaching, will achieve better results．For example, there are some aspects of study, like practical sessions, dealing with more subjective questions, or meeting the needs of an individual student, which require face-to-face human interaction, whereas the more mechanical aspects of learning, such as answers to clear-cut questions, can be managed simply and effectively in a remote environment using new technology．
Blended learning approaches have proven especially appropriate in language learning．For example, in an ELT （English Language Teaching ） environment, a simple scenario （剧情概要） might be a classroom session where a teacher asks a group of students to use a wiki to create a text． Students then go away and compose and edit the text remotely．During the next F2F session, the teacher express his opinion about their work．
1.What is the main idea of this passage?
A．Blended learning is an effective learning approach．
B．More and more people will use Internet-based learning materials,
C．There are so many different ways of learning for people to choose in today's world．
D．Blended learning methods have proven to be effective except in language learning．
2.Which of the following aspects of study doesn't require face-to-face interaction between teachers and students?
A．Practical sessions．
B．Tackling the needs of an individual student．
C．Dealing with more subjective questions．
D．Providing answers to clear-cut questions．
3.It can be inferred from the passage that ______．
A．the radio and TV in the past were of poor quality
B．people do not get audio materials through cassettes nowadays
C．it was not convenient for people to leam outside a classroom in the past
D．it was difficult to find a classroom with good learning conditions in the old days
4.Which of the following can be best describe the writer's attitude towards blended learning?
A．Critical． B．Objective （客观的） ．
C．Supportive． D．Neutral （中立的） ．
高三英语阅读理解中等难度题查看答案及解析
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There ______ many new words in lesson one, It is very easy.
A．is
B．aren’t
C．isn’t
D．are
高三英语单项填空中等难度题查看答案及解析
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When first ______ to the market, these new products in their company enjoyed a great success.
A. Introducing B.introduced C.to introduce D. being introduced
高三英语单项填空简单题查看答案及解析
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-The girls in blue are our new classmates. -I know _____.
A. these B. so C. such D. that
高三英语单项填空中等难度题查看答案及解析
，语言规范，内容合适，篇章连贯。