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Many research groups are testing “ink” made from silk proteins to print human tissues, even organs. The process is a less costly alternative to conventional 3-D printing with collagen, a key protein mainly existing in the mammal’s (哺乳动物) cells. Researchers in Assam, a state in India, are investigating using local silkworm species for the task—they recently submitted a patent for bioinks using a combination of proteins obtained from local silkworms. The scientists have woven them into tissue structures ranging from ears to heart.

Silk is a natural substance which is strong and completely biodegradable (可生物降解的), well suited for applications in tissue engineering. For instance, to bio-print an ear, researchers dissolve silk fibers. They carefully mix the sticky liquid with a patient’s stem cells, then build structures layer by layer with a 3-D printer. Finally, the cells grow and replace the silken proteins and finally change into a natural substance in human body.

Compared with common—used chemicals as adhesive (黏合剂), wild silk is also perfect to cross-link silky tissues, which helps to maintain a 3-D structure. Also, the wild silk has spots that cells naturally attach to, which allows cells to stick to the silk structure rapidly. “These silks are ideal candidates for bioinks because they can be combined to build strong human tissues” says Mandal, the lab’s lead investigator. “This is important, for example, when making bones,” he add.

“Obtaining and purifying collagen from animal remains is complex and expensive.” says David Kaplan, an expert in biomedical engineering, when asked about the advantages. Compared with collagen, silks have an immense advantage in terms of supply and processing. Local sourcing is also a clear plus in their use in India.”

Mandal and his colleagues have already created original structures, including bone and soft tissues of the heart and liver. Reconstructing a human knee complex tissue at the ends of a bone will be next.

1.What does the underlined word “bioinks” refer to?

A.Silk proteins. B.Collagens.

C.Certain chemical. D.Tissues.

2.What will a patient eventually get after an ear-bioprinting?

A.An artificial ear. B.A silken ear.

C.A real ear. D.An original ear.

3.What are the advantages of silk proteins over collagen according to David Kaplan?

A.They are biodegradable and strong.

B.They are inexpensive and uncomplicated.

C.They are harmless and attachable.

D.They are pure and available.

4.What is the best title for the text?

A.Final Solution—Wild Worms for Medical Treatment.

B.Silky Tissue—Worm Proteins Ready for 3-D Bioprinting.

C.Bioink—Cheap Alternative for Conventional Operations.

D.Protein—Key to Repairing Human Organs.

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